Blackwell B200 vs Instinct MI355X
Complete side-by-side comparison of specs, performance, memory, power efficiency, and pricing.
Blackwell B200
89
Spec Wins
Instinct MI355X
96
Detailed Specifications
Blackwell B200 — Best For
Instinct MI355X — Best For
Who Should Choose Each GPU?
Choose Blackwell B200 if you…
- ✓Need maximum CUDA/TensorRT/vLLM ecosystem compatibility
- ✓Have power-constrained data centers (1000W vs 1400W TDP)
- ✓Running Frontier Training workloads
- ✓Running AGI Research workloads
Choose Instinct MI355X if you…
- ✓Need more VRAM (288GB vs 192GB) for large model inference
- ✓Prioritize raw FP8 throughput (4,625 vs 4,500 TFLOPS)
- ✓Working with a tighter CapEx budget (lower list price)
- ✓Running LLM Training workloads
- ✓Running Frontier AI workloads
- ✓Running HPC workloads
Verdict
The Blackwell B200 and Instinct MI355X target different priorities. The Instinct MI355X's 288GB of HBM3e gives it a clear edge for large-model inference where fitting the full model in VRAM eliminates quantization overhead. For training throughput, the Instinct MI355X's 4,625 FP8 TFLOPS outpaces the Blackwell B200's 4,500 TFLOPS. Teams already invested in the NVIDIA/CUDA ecosystem will have less friction with the Blackwell B200, while teams open to ROCM can benefit from the Instinct MI355X's advantages. Use our TCO Calculator to model the full 3-year cost difference for your specific utilization and power costs.
Blackwell B200 vs Instinct MI355X: Common Questions
Which is faster, Blackwell B200 or Instinct MI355X?+
In FP8 throughput, the Instinct MI355X leads with 4,625 TFLOPS vs 4,500 TFLOPS. For LLM inference, memory capacity and bandwidth often matter more than raw TFLOPS — the Instinct MI355X has more VRAM (288GB).
Is Blackwell B200 or Instinct MI355X better for LLM training?+
For LLM training at scale, the Instinct MI355X has higher raw throughput. However, the choice also depends on your software stack: Blackwell B200 offers CUDA compatibility with the widest framework support (PyTorch, JAX, TensorRT).
What is the price difference between Blackwell B200 and Instinct MI355X?+
The Blackwell B200 is estimated at $35,000 per unit and the Instinct MI355X at $30,000. Actual pricing varies by vendor, volume, and configuration. Check our Buy page for current reseller pricing.
Which GPU is more power efficient, Blackwell B200 or Instinct MI355X?+
The Blackwell B200 has a lower TDP (1000W vs 1400W). Performance-per-watt depends on your workload — for FP8 inference, divide TFLOPS by TDP: Blackwell B200 = 4.5 TFLOPS/W vs Instinct MI355X = 3.3 TFLOPS/W.