Instinct MI325X vs Instinct MI300X
Complete side-by-side comparison of specs, performance, memory, power efficiency, and pricing.
Instinct MI325X
68
Spec Wins
Instinct MI300X
65
Detailed Specifications
Instinct MI325X — Best For
Instinct MI300X — Best For
Who Should Choose Each GPU?
Choose Instinct MI325X if you…
- ✓Need more VRAM (288GB vs 192GB) for large model inference
- ✓Running LLM Training workloads
- ✓Running ROCm Workloads workloads
Choose Instinct MI300X if you…
- ✓Working with a tighter CapEx budget (lower list price)
- ✓Running Large Models workloads
- ✓Running Cost-Effective Training workloads
Verdict
The Instinct MI325X and Instinct MI300X target different priorities. The Instinct MI325X's 288GB of HBM3e gives it a clear edge for large-model inference where fitting the full model in VRAM eliminates quantization overhead. Both GPUs use ROCM, so ecosystem switching cost is not a factor. Use our TCO Calculator to model the full 3-year cost difference for your specific utilization and power costs.
Instinct MI325X vs Instinct MI300X: Common Questions
Which is faster, Instinct MI325X or Instinct MI300X?+
In FP8 throughput, the Instinct MI300X leads with 2,614 TFLOPS vs 2,614 TFLOPS. For LLM inference, memory capacity and bandwidth often matter more than raw TFLOPS — the Instinct MI325X has more VRAM (288GB).
Is Instinct MI325X or Instinct MI300X better for LLM training?+
For LLM training at scale, the Instinct MI300X has higher raw throughput. However, the choice also depends on your software stack: Instinct MI300X offers CUDA compatibility with the widest framework support (PyTorch, JAX, TensorRT).
What is the price difference between Instinct MI325X and Instinct MI300X?+
The Instinct MI325X is estimated at $22,000 per unit and the Instinct MI300X at $15,000. Actual pricing varies by vendor, volume, and configuration. Check our Buy page for current reseller pricing.
Which GPU is more power efficient, Instinct MI325X or Instinct MI300X?+
The Instinct MI300X has a lower TDP (750W vs 750W). Performance-per-watt depends on your workload — for FP8 inference, divide TFLOPS by TDP: Instinct MI325X = 3.5 TFLOPS/W vs Instinct MI300X = 3.5 TFLOPS/W.