Hopper H100 SXM5 vs Instinct MI325X
Complete side-by-side comparison of specs, performance, memory, power efficiency, and pricing.
Hopper H100 SXM5
73
Spec Wins
Instinct MI325X
68
Detailed Specifications
Hopper H100 SXM5 — Best For
Instinct MI325X — Best For
Who Should Choose Each GPU?
Choose Hopper H100 SXM5 if you…
- ✓Need maximum CUDA/TensorRT/vLLM ecosystem compatibility
- ✓Prioritize raw FP8 throughput (3,958 vs 2,614 TFLOPS)
- ✓Have power-constrained data centers (700W vs 750W TDP)
- ✓Running LLM Training workloads
- ✓Running HPC workloads
Choose Instinct MI325X if you…
- ✓Need more VRAM (288GB vs 80GB) for large model inference
- ✓Working with a tighter CapEx budget (lower list price)
- ✓Running LLM Training workloads
- ✓Running ROCm Workloads workloads
Verdict
The Hopper H100 SXM5 and Instinct MI325X target different priorities. The Instinct MI325X's 288GB of HBM3e gives it a clear edge for large-model inference where fitting the full model in VRAM eliminates quantization overhead. For training throughput, the Hopper H100 SXM5's 3,958 FP8 TFLOPS outpaces the Instinct MI325X's 2,614 TFLOPS. Teams already invested in the NVIDIA/CUDA ecosystem will have less friction with the Hopper H100 SXM5, while teams open to ROCM can benefit from the Instinct MI325X's advantages. Use our TCO Calculator to model the full 3-year cost difference for your specific utilization and power costs.
Hopper H100 SXM5 vs Instinct MI325X: Common Questions
Which is faster, Hopper H100 SXM5 or Instinct MI325X?+
In FP8 throughput, the Hopper H100 SXM5 leads with 3,958 TFLOPS vs 2,614 TFLOPS. For LLM inference, memory capacity and bandwidth often matter more than raw TFLOPS — the Instinct MI325X has more VRAM (288GB).
Is Hopper H100 SXM5 or Instinct MI325X better for LLM training?+
For LLM training at scale, the Hopper H100 SXM5 has higher raw throughput. However, the choice also depends on your software stack: Hopper H100 SXM5 offers CUDA compatibility with the widest framework support (PyTorch, JAX, TensorRT).
What is the price difference between Hopper H100 SXM5 and Instinct MI325X?+
The Hopper H100 SXM5 is estimated at $25,000 per unit and the Instinct MI325X at $22,000. Actual pricing varies by vendor, volume, and configuration. Check our Buy page for current reseller pricing.
Which GPU is more power efficient, Hopper H100 SXM5 or Instinct MI325X?+
The Hopper H100 SXM5 has a lower TDP (700W vs 750W). Performance-per-watt depends on your workload — for FP8 inference, divide TFLOPS by TDP: Hopper H100 SXM5 = 5.7 TFLOPS/W vs Instinct MI325X = 3.5 TFLOPS/W.