Instinct MI350X vs Instinct MI300X
Complete side-by-side comparison of specs, performance, memory, power efficiency, and pricing.
Instinct MI350X
93
Spec Wins
Instinct MI300X
65
Detailed Specifications
Instinct MI350X — Best For
Instinct MI300X — Best For
Who Should Choose Each GPU?
Choose Instinct MI350X if you…
- ✓Need more VRAM (288GB vs 192GB) for large model inference
- ✓Prioritize raw FP8 throughput (4,614 vs 2,614 TFLOPS)
- ✓Running LLM Training workloads
- ✓Running AI Inference workloads
- ✓Running HPC workloads
Choose Instinct MI300X if you…
- ✓Have power-constrained data centers (750W vs 1000W TDP)
- ✓Working with a tighter CapEx budget (lower list price)
- ✓Running Large Models workloads
- ✓Running Cost-Effective Training workloads
Verdict
The Instinct MI350X and Instinct MI300X target different priorities. The Instinct MI350X's 288GB of HBM3e gives it a clear edge for large-model inference where fitting the full model in VRAM eliminates quantization overhead. For training throughput, the Instinct MI350X's 4,614 FP8 TFLOPS outpaces the Instinct MI300X's 2,614 TFLOPS. Both GPUs use ROCM, so ecosystem switching cost is not a factor. Use our TCO Calculator to model the full 3-year cost difference for your specific utilization and power costs.
Instinct MI350X vs Instinct MI300X: Common Questions
Which is faster, Instinct MI350X or Instinct MI300X?+
In FP8 throughput, the Instinct MI350X leads with 4,614 TFLOPS vs 2,614 TFLOPS. For LLM inference, memory capacity and bandwidth often matter more than raw TFLOPS — the Instinct MI350X has more VRAM (288GB).
Is Instinct MI350X or Instinct MI300X better for LLM training?+
For LLM training at scale, the Instinct MI350X has higher raw throughput. However, the choice also depends on your software stack: Instinct MI300X offers CUDA compatibility with the widest framework support (PyTorch, JAX, TensorRT).
What is the price difference between Instinct MI350X and Instinct MI300X?+
The Instinct MI350X is estimated at $25,000 per unit and the Instinct MI300X at $15,000. Actual pricing varies by vendor, volume, and configuration. Check our Buy page for current reseller pricing.
Which GPU is more power efficient, Instinct MI350X or Instinct MI300X?+
The Instinct MI300X has a lower TDP (750W vs 1000W). Performance-per-watt depends on your workload — for FP8 inference, divide TFLOPS by TDP: Instinct MI350X = 4.6 TFLOPS/W vs Instinct MI300X = 3.5 TFLOPS/W.